Integerrimides A and B. Two Cyclic Heptapeptides from the Latex of Jatropha integerrima

Publikations-Art

Zeitschriftenbeitrag (peer-reviewed)

Autoren

Mongkolvisut, W.; Sutthivaiyakit, S.; Leutbecher, H.; Mika, S.; Klaiber, I.; Moeller, W.; Roesner, H.; Beifuss, U.; Conrad, J.

Erscheinungsjahr

2006

Veröffentlicht in

J. Nat. Prod.

Band/Volume

69/10

DOI

10.1055/s-2007-986887

Seite (von - bis)

1435-1441

Two new cyclic heptapeptides, integerrimides A (I) and B (II), have been isolated from the latex of Jatropha integerrima. Their structures were elucidated by using extensive 1D and 2D NMR, MS, and chem. degrdn. At 50 μM both peptides 1 and 2 significantly inhibited neurite outgrowth in neuronal cell culture. They also partially inhibited proliferation of human IPC-298 melanoma cells as well as migration of human Capan II pancreatic carcinoma cells, but were inactive in HSV-1, antifungal, and antimalarial assays.