Pathobiology of Mycoplasma suis
- Publikations-Art
- Zeitschriftenbeitrag (peer-reviewed)
- Autoren
- Hoelzle LE, Zeder M , Felder KM, Hoelzle K
- Erscheinungsjahr
- 2014
- DOI
- 10.1016/j.tvjl.2014.07.023
- Schlagworte
- Pathogene, Schwein
Mycoplasma suis is an uncultivable bacterium lacking a cell wall that attaches to
and may invade the red blood cells of pigs. M. suis infections occur worldwide
and cause the pig industry serious economic losses due to the disease known as
infectious anaemia of pigs or, historically, porcine eperythrozoonosis.
Infectious anaemia of pigs is characterised predominantly by acute haemolytic or
chronic anaemia, along with non-specific manifestations, such as growth
retardation in feeder pigs and poor reproductive performance in sows. The
fastidious nature of M. suis, as well as the lack of an in vitro cultivation
system, has hampered the understanding of the biology and pathogenicity of this
organism. Pathogenetic mechanisms of M. suis include direct destruction of red
blood cells by adhesion, invasion, nutrient scavenging, immune-mediated lysis and
eryptosis, as well as endothelial targeting. Recently published genome sequences,
in combination with proteome analyses, have generated new insights into the
pathogenicity of M. suis. The present review combines these data with the
knowledge provided by experimental M. suis infections.