Concentrations of total curcuminoids in plasma, but not liver and kidney, are higher in 18- than in 3-months old mice
- Publikations-Art
- Zeitschriftenbeitrag (peer-reviewed)
- Autoren
- Alexa Kocher, Stephanie Hagl, Christina Schiborr, Gunter P. Eckert, Jan Frank
- Erscheinungsjahr
- 2015
- Veröffentlicht in
- NFS Journal
- Verlag
- Elsevier
- Band/Volume
- 1/
- DOI
- 10.1016/j.nfs.2015.03.002
- Seite (von - bis)
- Pages 3–8
Background
Curcuminoids (curcumin, demethoxycurcumin, bis-demethoxycurcumin) are lipophilic polyphenols thought to be effective in the prevention and treatment of neurodegenerative disorders, of which mitochondrial dysfunction is a prominent feature. In particular, older people may thus benefit from increasing their curcuminoid intake. However until now, it is not investigated if there exist age differences in the bioavailability of curcuminoids and therefore, it is unclear if curcumin doses have to be adjusted to age. Thus, we explored if the tissue concentrations and biological activities of curcuminoids are affected by age.