Concentrations of total curcuminoids in plasma, but not liver and kidney, are higher in 18- than in 3-months old mice

Publication Type
Journal contribution (peer reviewed)
Authors
Alexa Kocher, Stephanie Hagl, Christina Schiborr, Gunter P. Eckert, Jan Frank
Year of publication
2015
Published in
NFS Journal
Pubisher
Elsevier
Band/Volume
1/
DOI
10.1016/j.nfs.2015.03.002
Page (from - to)
Pages 3–8
Abstract

Background

Curcuminoids (curcumin, demethoxycurcumin, bis-demethoxycurcumin) are lipophilic polyphenols thought to be effective in the prevention and treatment of neurodegenerative disorders, of which mitochondrial dysfunction is a prominent feature. In particular, older people may thus benefit from increasing their curcuminoid intake. However until now, it is not investigated if there exist age differences in the bioavailability of curcuminoids and therefore, it is unclear if curcumin doses have to be adjusted to age. Thus, we explored if the tissue concentrations and biological activities of curcuminoids are affected by age.

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