Copper-Catalyzed Synthesis of Quinazolines in Water Starting from o-Bromobenzylbromides and Benzamidines

Publikations-Art

Zeitschriftenbeitrag (peer-reviewed)

Autoren

Malakar, C. C.; Baskakova, A.; Conrad, J.; Beifuss, U.

Erscheinungsjahr

2012

Veröffentlicht in

Chem. Eur. J.

Band/Volume

18/29

DOI

10.1002/chem.201200583

Seite (von - bis)

8882-8885

Water makes it possible: The Cu₂O-catalyzed reaction between easily available o-bromobenzylbromides and benzamidines by using Cs₂CO₃ as the base and N,N′-dimethylethylenediamine (DMEDA) as the additive in water as the solvent gives access to substituted quinazolines in a single step with yields ranging from 57 to 85 %.