Copper-Catalyzed Synthesis of Quinazolines in Water Starting from o-Bromobenzylbromides and Benzamidines

Publication Type: Journal contribution (peer reviewed)
Authors: Malakar, C. C.; Baskakova, A.; Conrad, J.; Beifuss, U.
Year of publication: 2012
Published in: Chem. Eur. J.
Band/Volume: 18/29
DOI: 10.1002/chem.201200583
Page (from - to): 8882-8885

Abstract

Water makes it possible: The Cu₂O-catalyzed reaction between easily available o-bromobenzylbromides and benzamidines by using Cs₂CO₃ as the base and N,N′-dimethylethylenediamine (DMEDA) as the additive in water as the solvent gives access to substituted quinazolines in a single step with yields ranging from 57 to 85 %.

Involved persons

Dr. rer. nat. Jürgen Conrad
Prof. Dr. rer. nat. Uwe Beifuß

Involved institutions

Institute of Chemistry
Bioorganic Chemistry