Copper(I)-Catalyzed Intramolecular O-Arylation for the Synthesis of 2,3,4,9-Tetrahydro-1H-xanthen-1-ones with Low Loads of CuCl
- Publikations-Art
- Zeitschriftenbeitrag (peer-reviewed)
- Autoren
- Sudheendran, K.; Malakar, C. C.; Conrad, J.; Beifuss, U.
- Erscheinungsjahr
- 2012
- Veröffentlicht in
- J. Org. Chem.
- Band/Volume
- 77/
- DOI
- 10.1021/jo3018318
- Seite (von - bis)
- 10194-10210
As little as 0.5 mol % CuCl is sufficient to catalyze the intramolecular O-arylation of easily accessible 2-(2-bromobenzyl)-cyclohexane-1,3-diones to provide the corresponding 2,3,4,9-tetrahydro-1H-xanthen-1-ones with yields ranging from 83 to 99%.