Copper(I)-Catalyzed Intramolecular O-Arylation for the Synthesis of 2,3,4,9-Tetrahydro-1H-xanthen-1-ones with Low Loads of CuCl

Publication Type
Journal contribution (peer reviewed)
Authors
Sudheendran, K.; Malakar, C. C.; Conrad, J.; Beifuss, U.
Year of publication
2012
Published in
J. Org. Chem.
Band/Volume
77/
DOI
10.1021/jo3018318
Page (from - to)
10194-10210
Abstract

As little as 0.5 mol % CuCl is sufficient to catalyze the intramolecular O-arylation of easily accessible 2-(2-bromobenzyl)-cyclohexane-1,3-diones to provide the corresponding 2,3,4,9-tetrahydro-1H-xanthen-1-ones with yields ranging from 83 to 99%.

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