Novobiocin biosynthesis in Streptomyces spheroides: identification of a dimethylallyl diphosphate: 4-hydroxyphenylpyruvate dimethylallyl transferase
- Publikations-Art
- Zeitschriftenbeitrag
- Autoren
- Steffensky, M.; Li, S.-M.;Vogler, B.; Heide, L.
- Erscheinungsjahr
- 1998
- Veröffentlicht in
- FEMS Microbiol. Lett.
- Band/Volume
- 161/1
- Seite (von - bis)
- 69-74
A dimethylallyl diphosphate: 4-hydroxyphenylpyruvate dimethylallyltransferase from the novobiocin producer Streptomyces spheroides DSM 40292 was identified, partially purified and characterized. The enzyme was sol., and specific for 4-hydroxyphenylpyruvate and dimethylallyl diphosphate as substrates. It is most likely involved in the biosynthesis of the prenylated 4-hydroxybenzoate moiety of the aminocoumarin antibiotic novobiocin