Novobiocin biosynthesis in Streptomyces spheroides: identification of a dimethylallyl diphosphate: 4-hydroxyphenylpyruvate dimethylallyl transferase

Publication Type: Journal contribution
Authors: Steffensky, M.; Li, S.-M.;Vogler, B.; Heide, L.
Year of publication: 1998
Published in: FEMS Microbiol. Lett.
Band/Volume: 161/1
Page (from - to): 69-74

Abstract

A dimethylallyl diphosphate: 4-hydroxyphenylpyruvate dimethylallyltransferase from the novobiocin producer Streptomyces spheroides DSM 40292 was identified, partially purified and characterized. The enzyme was sol., and specific for 4-hydroxyphenylpyruvate and dimethylallyl diphosphate as substrates. It is most likely involved in the biosynthesis of the prenylated 4-hydroxybenzoate moiety of the aminocoumarin antibiotic novobiocin

Involved institutions

Institute of Chemistry
Bioorganic Chemistry