Synthesis of new 1H-1,2,4-triazolylcoumarins and their antitumor and anti-HIV activities.
- Publikations-Art
- Zeitschriftenbeitrag (peer-reviewed)
- Autoren
- Al-Soud, Y. A.; Al-Masoudi, I. A.; Saeed, B.; Beifuss, U.; Al-Masoudi, N. A.
- Erscheinungsjahr
- 2006
- Veröffentlicht in
- Chemistry of Heterocyclic Compounds
- Band/Volume
- 42/5
- DOI
- 10.1007/s10593-006-0130-2
- Seite (von - bis)
- 583-590
A variety of 7-[(1,5-dialkyl-1H-1,2,4-triazolyl)methoxy(and methyl)]coumarins, e.g., I, were synthesized from cycloaddn. of 2-(2H-benzopyran-7-yloxy)acetonitrile and 2-(5-methoxy-4-methyl-2H-benzopyran-7-yl)acetonitrile (II), resp., with various reactive cumulene >C+N++N- intermediates via spontaneous rearrangements. The anticancer (breast, lung, CNS cancers) and antiviral (HIV-1, HIV-2) properties of some compds. were investigated in vitro. I showed some inhibition of HIV-1.