Synthesis of new 1H-1,2,4-triazolylcoumarins and their antitumor and anti-HIV activities.

Publication Type
Journal contribution (peer reviewed)
Authors
Al-Soud, Y. A.; Al-Masoudi, I. A.; Saeed, B.; Beifuss, U.; Al-Masoudi, N. A.
Year of publication
2006
Published in
Chemistry of Heterocyclic Compounds
Band/Volume
42/5
DOI
10.1007/s10593-006-0130-2
Page (from - to)
583-590
Abstract

A variety of 7-[(1,5-dialkyl-1H-1,2,4-triazolyl)methoxy(and methyl)]coumarins, e.g., I, were synthesized from cycloaddn. of 2-(2H-benzopyran-7-yloxy)acetonitrile and 2-(5-methoxy-4-methyl-2H-benzopyran-7-yl)acetonitrile (II), resp., with various reactive cumulene >C+N++N- intermediates via spontaneous rearrangements. The anticancer (breast, lung, CNS cancers) and antiviral (HIV-1, HIV-2) properties of some compds. were investigated in vitro. I showed some inhibition of HIV-1.

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