The first enzymatic Achmatowicz reaction: selective laccase-catalyzed synthesis of 6-hydroxy-(2H)-pyran-3(6H)-ones and (2H)-pyran-2,5(6H)-diones

Publikations-Art
Zeitschriftenbeitrag (peer-reviewed)
Autoren
Asta, C.; Schmidt, D.; Conrad, J.; Förster-Fromme, B.; Tolasch, T.; Beifuss, U.
Erscheinungsjahr
2013
Veröffentlicht in
RSC Adv.
Band/Volume
3/
DOI
10.1039/C3RA44107E
Seite (von - bis)
19259-19263
Abstract

The laccase-catalyzed oxidation of (5-alkylfuran-2-yl)carbinols using aerial oxygen as an oxidant selectively affords 6-hydroxy-(2H)-pyran-3(6H)-ones with yields up to 90%. With suitable substituted furan-2-yl carbinols as substrates the procedure allows the efficient preparation of (2H)-pyran-2,5(6H)-diones in a single step.

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