Fecal microbiota transplantation
- Status
- current
Description
Clostridium difficile infection can serve as a model to study the dysbiotic microbiota resulting from severe disruption of gastrointestinal homeostasis by antibiotic treatment or other microbiota stressors. Fecal microbiota transplantion has a high success rate for the treatment of recurrent Clostridium difficile infection and represents the only clinically validated therapeutic form of microbiota manipulation so far. The goal of my group is to study microbial events before and after fecal microbiota transplantation in patients with recurrent Clostridium difficile infection in order to improve our understanding of the dysbiotic microbiota state as well as short- and longterm effects of the treatment.
Involved persons
Involved institutions
Publications in the course of the project
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Efficacy of combined jejunal and colonic fecal microbiota transplantation for recurrent Clostridium difficile Infection.
2014: Dutta SK, Girotra M, Garg S, Dutta A, von Rosenvinge EC, Maddox C, Song Y, Bartlett JG, Vinayek R, Fricke WF.
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Efficacy of fecal microbiota transplantation in 2 children with recurrent Clostridium difficile infection and its impact on their growth and gut microbiome.
2014: Walia R, Garg S, Song Y, Girotra M, Cuffari C, Fricke WF, Dutta SK.
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Microbiota dynamics in patients treated with fecal microbiota transplantation for recurrent Clostridium difficile infection.
2013: Song Y, Garg S, Girotra M, Maddox C, von Rosenvinge EC, Dutta A, Dutta S, Fricke WF.