A new laccase-catalyzed domino process and its application to the efficient synthesis of 2-aryl-1H-benzimidazoles

Publication Type
Journal contribution (peer reviewed)
Authors
Leutbecher, H.; Constantin, M.; Mika, S.; Conrad, J.; Beifuss, U.
Year of publication
2011
Published in
Tetrahedron Lett.
Band/Volume
52/5
DOI
10.1016/j.tetlet.2010.11.145
Page (from - to)
605-608
Abstract

The laccase-catalyzed domino reaction of o-phenylenediamine and benzaldehydes with aerial oxygen as the oxidant exclusively yields 2-aryl-1H-benzimidazoles in good to very good yields. It is easy to perform under very mild reaction conditions.

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