Analysis of polymorphic microsatellites within the bovine and ovine prion protein (PRNP) genes

Publication Type
Journal contribution
Authors
Geldermann, H., S. Preuß, J. Eckert, Y. Han and K. Ollesch
Year of publication
2003
Published in
Anim. Gen.
Band/Volume
34/
Page (from - to)
283-289
Abstract

Twenty-four microsatellite sites with at least three repeats were found in the bovine prion protein gene (PRNP) and 23 in the ovine PRNP gene. Eight microsatellite sites were polymorphic in cattle and six in sheep with up to ten alleles per site. In many cases allelic DNA fragments had variants in microsatellite sites as well as in flanking regions. Distances between microsatellite sites in eight genes from cattle and sheep occurred on average every 0.9 kb. The numerous polymorphic microsatellite sites will improve analysis of phylogenetic origin of different PRNP alleles and trait association studies for BSE and scrapie.

Involved persons