Laccase-catalyzed oxidation of Hantzsch 1,4-dihydropyridines and a new one pot synthesis of pyridines

Publication Type
Journal contribution (peer reviewed)
Authors
Abdel-Mohsen, H. T.; Conrad, J.; Beifuss, U.
Year of publication
2012
Published in
Green Chem.
Band/Volume
14/
DOI
10.1039/C2GC35950B
Page (from - to)
2686-2690
Abstract

The laccase-catalyzed oxidation of 1,4-dihydropyridines to pyridines using aerial O2 as the oxidant exclusively delivers pyridines with yields up to 95% under mild reaction conditions. Combination of the Hantzsch 1,4-dihydropyridine synthesis with the newly developed laccase-catalyzed oxidation forms the basis of a facile and environmentally benign method for the synthesis of pyridines in one pot.

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