Synthesis of 2-Aryl-1,2-dihydrophthalazines via Reaction of 2-(Bromomethyl)benzaldehydes with Arylhydrazines

Publication Type: Journal contribution (peer reviewed)
Authors: Aljaar, N.; Conrad, J.; Beifuss, U.
Year of publication: 2013
Published in: J. Org. Chem.
Band/Volume: 78/
DOI: 10.1021/jo302491x
Page (from - to): 1045-1053

Abstract

The reaction of 2-(bromomethyl)benzaldehydes with arylhydrazines employing K₂CO₃ as a base and FeCl₃ as a catalyst in CH₃CN at 100 °C delivers 2-aryl-1,2-dihydrophthalazines with yields ranging from 60 to 91%. The transformation is considered to proceed as an intermolecular condensation/intramolecular nucleophilic substitution.

Involved persons

Dr. rer. nat. Jürgen Conrad
Prof. Dr. rer. nat. Uwe Beifuß

Involved institutions

Institute of Chemistry
Bioorganic Chemistry