Bioassay guided isolation of a new C18-polyacetylene, (+)-9(Z),17-octadecadiene-12,14-diyne-1,11,16-triol, from Cussonia barterii

Publication Type
Journal contribution
Authors
Papajewski, S.; Guse, J.-H.; Klaiber, I.; Roos, G.; Suessmuth, R.; Vogler, B.; Walter, C. U.; Kraus, W.
Year of publication
1998
Published in
Planta Med. (1998), 64(5), 479-481
Band/Volume
64/5
Page (from - to)
479-81
Abstract

A novel C18-polyacetylene, (+)-9(Z),17-octadecadiene-12,14-diyne-1,11,16-triol, has been isolated from the Et acetate ext. of Cussonia barterii (Araliaceae) leaves collected in Cameroon. The structure detn. was achieved by NMR, mass, IR, and UV spectroscopy. The new polyenyne shows antibacterial activity against Bacillus subtilis and Pseudomonas fluorescens, antifungal activity against Cladosporium cucumerinum, molluscicidal activity against Biomphalaria glabrata at low concns., and in addn. it possesses hemolytic activity.

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